Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against
hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: …

Cancer nanotherapeutics are progressing at a steady rate; research and development in
the field has experienced an exponential growth since early 2000's. The path to the …

Background The dynamic changes of lymphocyte subsets and cytokines profiles of patients
with novel coronavirus disease (COVID-19) and their correlation with the disease severity …

Measuring gene expression in individual cells is crucial for understanding the gene regulatory
network controlling human embryonic development. Here we apply single-cell RNA …

The draft genome of the pear (Pyrus bretschneideri) using a combination of BAC-by-BAC and
next-generation sequencing is reported. A 512.0-Mb sequence corresponding to 97.1% of …

Long-term antibody responses and neutralizing activities in response to SARS-CoV-2
infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies …

Most solid tumors possess unique pathophysiological characteristics that are not observed
in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, …

Genome editing has potential for the targeted correction of germline mutations. Here we
describe the correction of the heterozygous MYBPC3 mutation in human preimplantation …

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-…

Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation
of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 …