Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

For several decades, our understanding of the pathogenesis of unstable atherosclerotic
lesions has continued to grow. A consistent picture of unstable plaque structure …

Although recent studies have revealed that heart cells are generated in adult mammals, the
frequency of generation and the source of new heart cells are not yet known. Some studies …

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-
Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria …

The most common form of heart failure occurs with normal systolic function and often
involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive …

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by
exposure to a young circulation, suggesting that young blood contains humoral …

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural
stem cell behavior by providing circulating and secreted factors. Age-related decline of …

BACKGROUND Although rupture of an atherosclerotic plaque is considered to be the cause
of most acute coronary syndromes, the mechanism of plaque rupture is controversial …