Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
Background USA300, a clone of meticillin-resistant Staphylococcus aureus, is a major
source of community-acquired infections in the USA, Canada, and Europe. Our aim was to …
source of community-acquired infections in the USA, Canada, and Europe. Our aim was to …
Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management
AJ Cooper, LV Sequist, JJ Lin - Nature Reviews Clinical Oncology, 2022 - nature.com
The discoveries of EGFR mutations and ALK rearrangements as actionable oncogenic
drivers in non-small-cell lung cancer (NSCLC) has propelled a biomarker-directed treatment …
drivers in non-small-cell lung cancer (NSCLC) has propelled a biomarker-directed treatment …
Targeting ALK: precision medicine takes on drug resistance
JJ Lin, GJ Riely, AT Shaw - Cancer discovery, 2017 - AACR
Anaplastic lymphoma kinase (ALK) is a validated molecular target in several ALK-
rearranged malignancies, including non–small cell lung cancer. However, the clinical …
rearranged malignancies, including non–small cell lung cancer. However, the clinical …
A symbolic representation of time series, with implications for streaming algorithms
The parallel explosions of interest in streaming data, and data mining of time series have
had surprisingly little intersection. This is in spite of the fact that time series data are typically …
had surprisingly little intersection. This is in spite of the fact that time series data are typically …
Experiencing SAX: a novel symbolic representation of time series
Many high level representations of time series have been proposed for data mining,
including Fourier transforms, wavelets, eigenwaves, piecewise polynomial models, etc …
including Fourier transforms, wavelets, eigenwaves, piecewise polynomial models, etc …
Hot sax: Efficiently finding the most unusual time series subsequence
In this work, we introduce the new problem of finding time series discords. Time series
discords are subsequences of a longer time series that are maximally different to all the rest …
discords are subsequences of a longer time series that are maximally different to all the rest …
Differential roles of microglia and monocytes in the inflamed central nervous system
R Yamasaki, H Lu, O Butovsky, N Ohno… - Journal of Experimental …, 2014 - rupress.org
In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …
Clustering of time-series subsequences is meaningless: implications for previous and future research
Given the recent explosion of interest in streaming data and online algorithms, clustering of
time-series subsequences, extracted via a sliding window, has received much attention. In …
time-series subsequences, extracted via a sliding window, has received much attention. In …
[PDF][PDF] A phase Ib trial of personalized neoantigen therapy plus anti-PD-1 in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer
PA Ott, S Hu-Lieskovan, B Chmielowski, R Govindan… - Cell, 2020 - cell.com
Neoantigens arise from mutations in cancer cells and are important targets of T cell-
mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a …
mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a …
Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK …
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510
(sotorasib), have demonstrated efficacy in KRAS G12C-mutant cancers, including non–small …
(sotorasib), have demonstrated efficacy in KRAS G12C-mutant cancers, including non–small …