Abstract
Purpose
Older people are at risk of potentially inappropriate prescribing (PIP) due to polypharmacy arising from multi-morbidity. Despite available explicit criteria to reduce PIP, it is highly prevalent. Whilst community pharmacists have the required knowledge to help reduce PIP, they are not currently engaged with the problem. This study explores the views of community pharmacists on their potential involvement in reducing PIP and determines the challenges to its implementation.
Methods
Semi-structured interviews with pharmacists working in community pharmacies in Ireland. The theoretical domains framework (TDF) was used to develop the topic guide and to analyse the transcripts. Domains of highest relevance for PIP reduction were identified based on their frequency or whether the participants emphasised the impact of constructs within a domain. Local ethical approval was obtained.
Results
Of 18 participants, 12 were female, median age was 30 years (IQR, 27–35) with a median of 6 years (IQR, 3–8) of experience. Seven TDF domains were identified as relevant to PIP reduction. Pharmacists were uncertain about their role in reducing PIP and reluctant to challenge physicians’ prescribing decisions. Challenges pertained to the environment, knowledge, social influences, professional role and identity.
Conclusions
Pharmacists welcomed new responsibilities in reducing PIP as part of their daily practice but expressed a need for removal of social and environmental barriers as well as, provision of relevant guidelines and education about PIP. This study provides useful insights into the target domains for overcoming barriers of pharmacist involvement in reducing PIP.
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Notes
The supervising/superintendent pharmacists is the person responsible for the day-to-day management and operation of the pharmacy and must have a minimum of 3 years post-registration experience (http://www.thepsi.ie/gns/Pharmacy_Practice/practice-guidance/Guidance_for_pharmacists/Guidance_for_Supervising_Pharmacists.aspx).
References
O'Mahony D, O'Sullivan C, Byrne S, O'Connor MN, Ryan C, Gallagher P (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44(2):213–218. https://doi.org/10.1093/ageing/afu145
Gallagher PF, O'Connor MN, O'Mahony D (2011) Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther 89(6):845–854. https://doi.org/10.1038/clpt.2011.44
Ryan C, O'Mahony D, Kennedy J, Weedle P, Byrne S (2009) Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol 68(6):936–947. https://doi.org/10.1111/j.1365-2125.2009.03531.x
Bruin-Huisman L, Abu-Hanna A, van Weert HC, Beers E (2017) Potentially inappropriate prescribing to older patients in primary care in the Netherlands: a retrospective longitudinal study. Age Ageing 46(4):614–619. https://doi.org/10.1093/ageing/afw243
Moriarty F, Bennett K, Fahey T, Kenny RA, Cahir C (2015) Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people. Eur J Clin Pharmacol 71:473–482. https://doi.org/10.1007/s00228-015-1815-1
Hamilton H, Gallagher P, Ryan C, Byrne S, O'Mahony D (2011) Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med 171(11):1013–1019. https://doi.org/10.1001/archinternmed
van der Stelt CA, Vermeulen Windsant-van den Tweel AM, Egberts AC (2016) The association between potentially inappropriate prescribing and medication-related hospital admissions in older patients: a nested case control study. Drug Saf 39:79–87. https://doi.org/10.1007/s40264-015-0361-1
Cahir C, Bennett K, Teljeur C, Fahey T (2014) Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients. Br J Clin Pharmacol 77(1):201–210. https://doi.org/10.1111/bcp.12161
Moriarty F, Bennett K, Cahir C, Kenny RA, Fahey T (2016) Potentially inappropriate prescribing according to STOPP and START and adverse outcomes in community-dwelling older people: a prospective cohort study. Br J Clin Pharmacol 82(3):849–857. https://doi.org/10.1111/bcp.12995
Bradley MC, Fahey T, Cahir C, Bennett K, O'Reilly D, Parsons C, Hughes CM (2012) Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland enhanced prescribing database. Eur J Clin Pharmacol 68(10):1425–1433. https://doi.org/10.1007/s00228-012-1249-y
Castillo-Paramo A, Claveria A, Verdejo Gonzalez A, Rey Gomez-Serranillos I, Fernandez-Merino MC, Figueiras A (2014) Inappropriate prescribing according to the STOPP/START criteria in older people from a primary care setting. Eur J Gen Pract 20(4):281–289. https://doi.org/10.3109/13814788.2014.899349
O'Connor MN, O'Sullivan D, Gallagher PF, Eustace J, Byrne S, O'Mahony D (2016) Prevention of hospital-acquired adverse drug reactions in older people using screening tool of older Persons’ prescriptions and screening tool to alert to right treatment criteria: a cluster randomized controlled trial. J Am Geriatr Soc 64(8):1558–1566. https://doi.org/10.1111/jgs.14312
Beers MH (1997) Explicit criteria for determining potentially inappropriate medication use by the elderly. Arch Intern Med 157:1531–1536. https://doi.org/10.1001/archinte.1997.00440350031003
Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC (1991) Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 151(9):1825–1832. https://doi.org/10.1001/archinte.1991.00400090107019
Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH (2003) Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163(22):2716–2724. https://doi.org/10.1001/archinte.163.22.2716
American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults (2012) J Am Geriatr Soc 60(4):616–631. https://doi.org/10.1111/j.1532-5415.2012.03923.x
American Geriatrics Society 2015 updated Beers Criteria for potentially inappropriate medication use in older adults (2015) J Am Geriatr Soc 63(11):2227–2246. https://doi.org/10.1111/jgs.13702
Dalleur O, Boland B, Losseau C, Henrard S, Wouters D, Speybroeck N, Degryse JM, Spinewine A (2014) Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging 31(4):291–298. https://doi.org/10.1007/s40266-014-0157-5
Frankenthal D, Lerman Y, Kalendaryev E, Lerman Y (2014) Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc 62(9):1658–1665 1658p. https://doi.org/10.1111/jgs.12993
Blenkinsopp A, Bond C, Raynor DK (2012) Medication reviews. Br J Clin Pharmacol 74(4):573–580. https://doi.org/10.1111/j.1365-2125.2012.04331.x
O'Riordan D, Walsh K, Galvin R, Sinnott C, Kearney PK, Byrne S (2016) The effect of pharmacist-led interventions in optimising prescribing in older adults in primary care: a systematic review. Sage Open Med 4:1–18. https://doi.org/10.1177/2050312116652568
Milos V, Rekman E, Bondesson A, Eriksson T, Jakobsson U, Westerlund T, Midlov P (2013) Improving the quality of pharmacotherapy in elderly primary care patients through medication reviews: a randomised controlled study. Drugs Aging 30(4):235–246. https://doi.org/10.1007/s40266-013-0057-0
Patterson BJ, Solimeo SL, Stewart KR, Rosenthal GE, Kaboli PJ, Lund BC (2015) Perceptions of pharmacists’ integration into patient-centered medical home teams. Res Social Adm Pharm 11(1):85–95. https://doi.org/10.1016/j.sapharm.2014.05.005
Vinks T, Egberts TCG, de Lange TM, de Koning FHP (2009) Pharmacist-based medication review reduces potential drug-related problems in the elderly the SMOG controlled trial. Drugs Aging 26(2):123–133. https://doi.org/10.2165/0002512-200926020-00004
Bergman AA, Jaynes HA, Gonzalvo JD, Hudmon KS, Frankel RM, Kobylinski AL, Zillich AJ (2016) Pharmaceutical role expansion and developments in pharmacist-physician communication. Health Commun 31(2):161–170. https://doi.org/10.1080/10410236.2014.940672
Schindel TJ, Yuksel N, Breault R, Daniels J, Varnhagen S, Hughes CA (2017) Perceptions of pharmacists’ roles in the era of expanding scopes of practice. Res Social Adm Pharm 13(1):148–161. https://doi.org/10.1016/j.sapharm.2016.02.007
Keller ME, Kelling SE, Cornelius DC, Oni HA, Bright DR (2015) Enhancing practice efficiency and patient care by sharing electronic health records. American Health Information Management Association. http://perspectives.ahima.org/enhancing-practice-efficiency-and-patient-care-by-sharing-electronic-health-records/. Accessed 20 February 2018
Duncan EM, Francis JJ, Johnston M, Davey P, Maxwell S, McKay GA, McLay J, Ross S, Ryan C, Webb DJ, Bond C (2012) Learning curves, taking instructions, and patient safety: using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors. Implement Sci 7:86. https://doi.org/10.1186/1748-5908-7-86
Dyson J, Lawton R, Jackson C, Cheater F (2011) Does the use of a theoretical approach tell us more about hand hygiene behaviour? The barriers and levers to hand hygiene. J Infect Prev 12(1):17–24. https://doi.org/10.1177/1757177410384300
Michie S, Johnston M, Abraham C, Lawton R, Parker D, Walker A (2005) Making psychological theory useful for implementing evidence based practice: a consensus approach. Qual Saf Health Care 14(1):26–33. https://doi.org/10.1136/qshc.2004.011155
Cane J, O’Connor D, Michie S (2012) Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci 7(1):37. https://doi.org/10.1186/1748-5908-7-37
McKenzie JE, French SD, O'Connor DA, Grimshaw JM, Mortimer D, Michie S, Francis J, Spike N, Schattner P, Kent PM, Buchbinder R, Green SE (2008) IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT): cluster randomised controlled trial study protocol. Implement Sci 3(1):11. https://doi.org/10.1186/1748-5908-3-11
Cullinan S, Fleming A, O'Mahony D, Ryan C, O'Sullivan D, Gallagher P, Byrne S (2015) Doctors’ perspectives on the barriers to appropriate prescribing in older hospitalized patients: a qualitative study. Br J Clin Pharmacol 79(5):860–869. https://doi.org/10.1111/bcp.12555
Pitt VJ, O'Connor D, Green S (2008) Referral of people with osteoarthritis to self-management programmes: barriers and enablers identified by general practitioners. Disabil Rehabil 30(25):1938–1946. https://doi.org/10.1080/09638280701774233
Cardwell K, Hughes CM, Ryan C (2018) Community pharmacists’ views of using a screening tool to structure medicines use reviews for older people: findings from qualitative interviews. Int J Clin Pharm. https://doi.org/10.1007/s11096-018-0659-z
Rodondi N, Trelle S, Spinewine A (2015) OPERAM: optimising therapy to prevent avoidable hospital admissions in the multimorbid elderly. http://operam-2020.eu/. Accessed 04 December 2016
O’Mahony D, Byrne S, Postea O (2015) SENATOR: software engine for the assessment and optimization of drug and non-drug therapy in older persosns. University College Cork. http://www.senator-project.eu/home/. Accessed 02 December 2016
Deprivation - Pobal HP Deprivation Indices. Pobal - Government Supporting Communities. https://maps.pobal.ie/. Accessed 03 May 2017
Francis JJ, Johnston M, Robertson A (2010) What is an adequate sample size? Operationalising data saturation for theory-based interview studies. Psychol Health 25(10):1229–1245
Farrell B, Black CD, Thompson W, McCarthy L, Rojas-Fernandez C, Lochnan H, Shamji S, Welch V, Bouchard M, Upshur R (2017) Deprescribing antihyperglycemic agents in older persons: evidence-based clinical practice guideline for deprescribing antihyperglycemics. Can Fam Physician 63(11):832–843
Bjerre LM, Farrell B, Hogel M, Graham L, Lemay G, McCarthy L, Raman Wilms L, Rojas-Fernandez C, Sinha S, Thompson W, Welch V, Wiens A (2018) Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia. Can Fam Physician 64(1):17–27
Pottie K, Thompson W, Davies S, Grenier J, Sadowski C, Welch V, Holbrook A, Boyd CM, Swenson JR, Ma A, Farrell B (2018) Deprescribing benzodiazepine receptor agonists. Can Fam Physician 64(5):339–351
Farrell B, Pottie K, Thompson W, Boghossian T, Pizzola L, Rashid FJ (2017) Deprescribing proton pump inhibitors. Evidence-based clinical practice guidelines. Can Fam Physician 63(5):354–364
Green J, Thorogood N (2014) In-depth interviews. In: Seaman J (ed) Qualitative Methods for Health Research, 3rd edn. SAGE, Great Britain, pp 95–125
Hsieh HF, Shannon SE (2005) Three approaches to qualitative content analysis. Qual Health Res 15(9):1277–1288. https://doi.org/10.1177/1049732305276687
Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D (2008) STOPP (screening tool for older Person’s prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther 46(2):72–83
National Institute for Health and Care Excellence (2017) Clinical guidelines. NICE guidelines. https://www.nice.org.uk/guidance. Accessed Feb 20 2018
Cullinan S, Hansen CR, Byrne S, O'Mahony D, Kearney PM, Sahm LJ (2016) Challenges of deprescribing in the multimorbid patient. Eur J Hosp Pharm 24:43–46. https://doi.org/10.1136/ejhpharm-2016-000921
Farrell B, Tsang C, Raman-Wilms L, Irving H, Conklin J, Pottie K (2015) What are priorities for deprescribing for elderly patients? Capturing the voice of practitioners: a modified delphi process. PLoS One 10(4):e0122246. https://doi.org/10.1371/journal.pone.0122246
Fried TR, Tinetti ME, Iannone MA (2011) Primary care clinicians’ experiences with treatment decision-making for older persons with multiple conditions. Arch Intern Med 171(1):75–80. https://doi.org/10.1001/archinternmed.2010.318
Reeve E, Farrell B, Thompson W, Herrmann N, Sketris I, Magin P, Chenoweth L, Gorman M, Quirke L, Bethune G, Forbes F, Hilmer S (2018) Evidence-based clinical practice guideline for deprescribing cholinesterase inhibitors and memantine. The University of Sydney, Sydney
Lavan AH, Gallagher P, Parsons C, O'Mahony D (2017) STOPPFrail (screening tool of older persons prescriptions in frail adults with limited life expectancy): consensus validation. Age Ageing 46(4):600–607. https://doi.org/10.1093/ageing/afx005
Acknowledgements
The authors would like to acknowledge all pharmacists who took part in this study for their time and interest in the study.
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Ethical approval for this study was granted by the Clinical Research Ethics Committee of the Cork Teaching Hospitals prior to recruitment. Written informed consent was obtained from all participants included in the study.
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The authors declare that they have no conflict of interest.
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Hansen, C.R., Byrne, S., O’Mahony, D. et al. Qualitative analysis of community pharmacists’ opinions on their involvement in reducing potentially inappropriate prescribing. Eur J Clin Pharmacol 75, 265–274 (2019). https://doi.org/10.1007/s00228-018-2578-2
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DOI: https://doi.org/10.1007/s00228-018-2578-2