Clinical symptoms observed in patients with COVID-19
Symptom | No. of studies | No. of patients | Heterogeneity | Model | Meta-analysis | ||
P value | I2 (%) | R (95% CI) | P value | ||||
Fever | 51 | 8473 | <0.001 | 95.9 | Random | 0.784 (0.736 to 0.828) | <0.001 |
Cough | 52 | 8539 | <0.001 | 97.2 | Random | 0.583 (0.515 to 0.649) | <0.001 |
Fatigue | 45 | 7848 | <0.001 | 96.9 | Random | 0.340 (0.277 to 0.405) | <0.001 |
Myalgia | 37 | 5625 | <0.001 | 93.0 | Random | 0.219 (0.177 to 0.264) | <0.001 |
Headache | 34 | 6414 | <0.001 | 88.5 | Random | 0.113 (0.089 to 0.140) | <0.001 |
Diarrhoea | 43 | 7904 | <0.001 | 87.5 | Random | 0.082 (0.064 to 0.102) | <0.001 |
Expectoration | 33 | 6408 | <0.001 | 95.8 | Random | 0.237 (0.185 to 0.294) | <0.001 |
Dyspnoea | 25 | 3670 | <0.001 | 87.5 | Random | 0.206 (0.133 to 0.290) | <0.001 |
Chest tightness | 30 | 5773 | <0.001 | 97.2 | Random | 0.229 (0.163 to 0.304) | <0.001 |
Nausea and vomiting | 24 | 4941 | <0.001 | 82.2 | Random | 0.066 (0.048 to 0.086) | <0.001 |
Pharyngalgia | 31 | 5947 | <0.001 | 88.7 | Random | 0.116 (0.090 to 0.145) | <0.001 |
Rhinorrhoea | 13 | 3111 | <0.001 | 91.2 | Random | 0.073 (0.042 to 0.113) | <0.001 |
Anorexia | 19 | 3274 | <0.001 | 96.9 | Random | 0.229 (0.143 to 0.326) | <0.001 |
Shivering | 16 | 4394 | <0.001 | 96.8 | Random | 0.152 (0.090 to 0.228) | <0.001 |
Asymptomatic | 10 | 878 | 0.002 | 66.3 | Random | 0.054 (0.031 to 0.084) | <0.001 |