Table 4

Analysis of clinical symptoms observed in patients with COVID-19, stratified by date of initial diagnosis*

Clinical symptomNo. of studiesNo. of patientsHeterogeneityModelMeta-analysis
P valueI2 (%)R (95% CI)P value
Fever
 Group 1518473<0.00195.9Random0.784 (0.736 to 0.828)<0.001
 Group 2142162<0.00197.9Random0.813 (0.667 to 0.924)<0.001
Fatigue
 Group 1457848<0.00196.9Random0.340 (0.277 to 0.405)<0.001
 Group 2111971<0.00193.9Random0.366 (0.268 to 0.470)<0.001
Cough<0.001
 Group 1528539<0.00197.2Random0.583 (0.515 to 0.649)<0.001
 Group 2142162<0.00186.6Random0.640 (0.574 to 0.703)<0.001
Myalgia<0.001
 Group 1375625<0.00193.0Random0.219 (0.177 to 0.264)<0.001
 Group 2101938<0.00191.7Random0.271 (0.193 to 0.358)<0.001
  • *Group 1: all patients; group 2: diagnosed before 31 January 2020.