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Abstract
Objective The current meta-analysis determined the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis.
Methods The CBM, CNKI, and MEDLINE databases were retrieved by computers. Domestic and international documents involving studies on the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis were collected from the database until May 2013, and statistical analysis was performed on all of the eligible results with RevMan5.0 software.
Results Eleven case-control studies were collected, including 1364 cases in the pulmonary tuberculosis group and 1496 cases in the control group.
The consolidated OR values and 95% confidence intervals of the case and control groups of HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 were 1.32 (1.09–1.60), 1.40 (1.01–1.93), and 1.36 (1.01–1.83), respectively.
Conclusion HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 may be susceptibility genes for pulmonary tuberculosis in a Chinese population.
- Pulmonary tuberculosis
- HLA-DRB1 gene
- Polymorphism
- Meta-analysis
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